Immunoadsorption in dilated cardiomyopathy
نویسندگان
چکیده
منابع مشابه
Immunoadsorption therapy reduces oxidative stress in patients with dilated cardiomyopathy
Several literatures have reported that the elimination of autoantibodies by immunoadsorption (IA) therapy induced shortand long-term improvements in cardiac function of patients with dilated cardiomyopathy (DCM). We assessed whether reduction in oxidative stress was related to the mechanism underlying left ventricular functional benefit from IA. We studied 7 patients with DCM (New York Heart As...
متن کاملRemoval of cardiodepressant antibodies in dilated cardiomyopathy by immunoadsorption.
OBJECTIVES The objective of this study was to investigate whether immunoadsorption (IA) removes cardiodepressant antibodies from the plasma of patients with dilated cardiomyopathy (DCM), as well as to describe their effects on isolated rat cardiomyocytes. BACKGROUND Immunoadsorption induces early hemodynamic improvement in patients with DCM. The mechanisms for this improvement remain to be el...
متن کاملImmunoadsorption Therapy for Patients with Dilated Cardiomyopathy and Heart Failure
Several autoantibodies directed against cardiac cellular proteins including G-protein-linked receptors, contractile proteins and mitochondrial proteins, have been identified in patients with dilated cardiomyopathy (DCM). Among these autoantibodies, anti-beta1-adrenoreceptor (AR) antibodies have long been discussed in terms of their pathogenetic role in DCM. Anti-beta1-AR antibody-positive patie...
متن کاملImmunohistological changes in dilated cardiomyopathy induced by immunoadsorption therapy and subsequent immunoglobulin substitution.
BACKGROUND Immunoadsorption (IA) and subsequent immunoglobulin (Ig) G substitution represent an additional therapeutic approach in dilated cardiomyopathy (DCM). It remains to be elucidated whether this treatment modulates myocardial inflammation, which is possibly a causal factor of ventricular dysfunction. METHODS AND RESULTS From 25 DCM patients (EF <30%), 12 patients were randomized for IA...
متن کامل[Familial dilated cardiomyopathy in patients transplanted for idiopathic dilated cardiomyopathy].
OBJECTIVE To evaluate the prevalence, clinical features, and pattern of inheritance of familial dilated cardiomyopathy (DCM) in heart transplant patients. PATIENTS AND METHOD Patients with idiopathic DCM who had undergone heart transplantation were invited to participate. Patients with alcohol abuse were excluded. A clinical evaluation, 12-lead ECG, echocardiogram, blood tests, and DNA extrac...
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ژورنال
عنوان ژورنال: Critical Care
سال: 2009
ISSN: 1364-8535
DOI: 10.1186/cc7443